Ratio Therapeutics Inc., a pharmaceutical company employing innovative technologies to develop best-in-class radiopharmaceuticals for cancer treatment and monitoring, announced that it entered into an agreement granting Macrocyclics Inc. exclusive manufacturing and distribution rights to Ratio’s proprietary chelator Macropa enabling broad access worldwide.
Health Technology Insights: Hoth Therapeutics Secures Japanese Patent for HT-KIT Platform Targeting Mast Cell Diseases
Macropa is a proprietary, best-in-class, bifunctional chelator for Actinium-225 (Ac-225), known for its strong alpha-particle emissions and its use in targeted alpha therapy (TAT) for the treatment of cancer. Macropa can be tethered to small molecules, peptides, and large polypeptides such as proteins and antibodies to enable the development of targeted radiopharmaceuticals for alpha radiotherapy. By rapidly and quantitatively complexing Ac-225 at room temperature, Macropa’s unique selectivity and stability for Ac-225 enables simple “one-pot” manufacturing and improves in vivo stability of the resulting compound.
“Over the past year, we have been focused on building global scientific awareness and encouraging adoption of our chelator platform across the therapeutic radiopharmaceutical community,” said Bill Cupelo, Chief Business Officer of Ratio. “We are proud to see our efforts realized through an expanding global ecosystem of collaborators who can now leverage Macropa to accelerate the development and adoption of radiopharmaceuticals worldwide. By enabling broader access to our platform, we are fostering a global community aligned in the mission to improve patient outcomes through targeted cancer therapies and diagnostics.”
Incorporated in 1995, Macrocyclics is a CDMO specialized in chelating agents for radiopharmaceuticals and nuclear medicine. The company maintains a broad catalog of bifunctional chelating agents that are used in R&D and clinical programs across the globe. Under the terms of the agreement, researchers from academia and industry may purchase Macropa directly from Macrocyclics, enabling rapid access in many countries including Japan, Canada, Australia and majority of Europe.
Health Technology Insights: Chatmeter Launches AI Tools for Healthcare, Integrates with WebMD and Vitals
“Ratio’s Macropa is a superior chelator for Ac-225,” said Paul Jurek, Ph.D., CEO of Macrocyclics. “The ability to label quickly at room temperature provides a critical advantage, especially when working with proteins or vectors that degrade when heated. We are excited to be the exclusive manufacturer of Macropa and plan to add multiple derivatives to our catalog and provide it under GMP conditions for innovators engaged in clinical research.”
Macrocyclics is an exhibitor at the 2025 SNMMI Annual Meeting, located in New Orleans, LA from June 21 to June 24. Ratio will also have representatives in attendance and will host a networking event for current and potential Macropa users.
Health Technology Insights: Olio Launches Referral and Care Coordination for Skilled Nursing Operators
To participate in our interviews, please write to our HealthTech Media Room at sudipto@intentamplify.com
Source – PR Newswire
